Impairment of Heart Rate Recovery After Peak Exercise Predicts Poor Outcome After Pediatric Heart Transplantation

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Impairment of heart rate recovery after peak exercise predicts poor outcome after pediatric heart transplantation.

BACKGROUND A blunted heart rate recovery (HRR) from peak exercise is associated with adverse outcome in adults with ischemic heart disease. We assessed HRR after pediatric heart transplantation (HTx) and its prognostic use. METHODS AND RESULTS Between 2004 and 2010 we performed 360 maximal exercise tests (median, 2 tests/patient; range, 1-7) in 128 children (66 men; age at test, 14 ± 3 years)...

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Heart rate after cardiac transplantation.

Two patients who have undergone heart transplantation 7 and 15 months previously were studied to determine basal heart rate, the effects of exercise, and acute changes in venous return and blood pressure as well as of vagal stimulation. In one case the effects of body temperature, isoprenaline (isoproterenol), beta blockade, and atropinization on heart rate were studied. Mean resting heart rate...

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Mechanism of the attenuated peak heart rate response to exercise after orthotopic cardiac transplantation.

The mechanism responsible for attenuation of the peak heart rate response to exercise in patients after cardiac transplantation was studied. Because the donor heart is believed to be surgically denervated, the peak heart rate response to exercise is dependent primarily on 1) an increase in the circulating levels of the catecholamines norepinephrine and epinephrine at peak exercise, and 2) the e...

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Test-retest reproducibility of heart rate recovery after treadmill exercise.

BACKGROUND Slowed heart rate recovery (HRR) of less than 12 beats per minute in the first minute after an exercise stress test has been suggested as a useful addition to the criteria currently used to assess exercise stress test results. Although HRR has been tested in large populations, the short-term test-retest stability (reproducibility) of abnormal HRR for an individual has not been assess...

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Abnormal heart rate recovery after exercise predicts coronary artery disease severity.

BACKGROUND Slow heart rate recovery (HRR) after exercise is considered to represent impaired parasympathetic tone and to be a predictor of all-cause and cardiovascular mortality, but the independent value of abnormal HRR in predicting the presence and severity of coronary artery disease (CAD) is unknown. The aim of this study was to evaluate these relationships in our patients. METHODS This p...

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ژورنال

عنوان ژورنال: Circulation

سال: 2013

ISSN: 0009-7322,1524-4539

DOI: 10.1161/circulationaha.112.000369